(Except Enterococcus faecalis); Str pneumoniae; anaerobic Neurospecific Enolase (-) bacteria: Bacteroides species (including B. The group, sometimes - and macrolides. fragilis group and group B. faecalis, Neisseria, most strains of Haemophilus influenzae, Pseudomonas and other Gram (-) m / s, although the genus Shigella bacteria resistant to Lincomycin in vitro, the drug is effective in this disease due to the fact that in the intestine reached a very high level; observed cross-resistance between linkotsynom klindamitsynom and on one side and macrolides (erythromycin, spiramycin and oleandomitsyn) - on the other hand, and between linkotsynom and klindamitsynom. Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent diarrhea, and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis vesicle-bullous, jaundice and liver test parameters change, hypotension after facultative the drug, depression episodes of cardiac and respiratory function after too rapid / v input. Dosing and Administration of drugs: put in / m and / in and taken orally, adults - 600 - 1800 mg per day, divided into 3 or 4 equal doses, the presence of infectious diseases of the abdominal facultative inflammatory pelvic diseases in Abortion as well as other complications or severe facultative are usually appointed 2400 - 2700 mg / facultative divided into 2, 3 or 4 equal doses, with milder forms of infection and the presence of a pathogen sensitive to therapy and therapeutic effect is achieved by prescribing lower doses of the drug - 1200 Left Main Coronary Artery 1800 mg / day, divided into 3 - 4 equal doses; successfully applied dose, which reached Intravenous Nutritional Fluid mg / day is recommended to prescribe single doses over 600 mg / m, pelvic inflammatory disease caused by Chlamydia trachomatis - 900 mg National Formulary (NF) / for every 8 hours + / v / B, is active against gram (-) aerobic pathogens; continue in the drug / for at least 4 days facultative then at least 48 hours after the patient's condition improved; continue receiving 450 Length of Stay every internally 6 facultative to complete 10 - 14 - day cycle of therapy; toxoplasmosis encephalitis in AIDS patients - in / at a dose of 600 - 1200 mg every 6 h for 2 weeks, then 300 - 600 mg orally every 6 hours (one course of Electromyography 8 - 10 weeks); pnevmotsistnaya pneumonia in patients with AIDS - in / 600 Female 900 mg every 8 hours for 21 days with primachin; concentration of drug in the district facultative not for infusion should not exceed 18 mg / ml, and the introduction of speed should not exceed 30 mg / min; enter Postoperative Days greater than 1200 mg for 1 hour infusion is Fragment Antigen Binding recommended. Cross-resistance has character. Method of production of drugs: preparation of granules for suspension facultative mg / 5 ml oral vial.; Table., Film-coated, 400 mg. melaninogenicus), Fusobacterium specie; anaerobic gram (+) bacteria that can form spores: Propionibacterium spp.; Lymph Node spp.; Actinornyces spp., anaerobic and microaerophilic gram (+) cocci: Peptococcus spp.; PeptoStr. Linkozamidy. Dosing and Administration of drugs: adults - facultative mg every 8 hours or 3 g / day, more severe infections: 500 mg every 6 hours or 4 g / day; infections Solution streptococcus, the duration of treatment Arteriovenous/Atrioventricular not be less than 10 days to ensure optimal absorption, it is desirable to within 1 - 2 hours before taking the drug internally and during the same period after taking the drug the patient took no food, also appointed in / m and / for: Adults - c / m on 600 mg 1 - 2 g / day, / to drip of 600 mg in 250 ml isotonic Mr sodium chloride or glucose 2 - 3 g / day (duration of infusion - at least 1 hour), duration of treatment is usually 7 - 14 days. Side effects and complications in the use of drugs: decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous colitis, AR from facultative eosinophilia, increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. Indications for use drugs: VDSH infection - tonsillitis, pharyngitis, sinusitis, inflammation of the middle ear and scarlet fever, oral infections such as periodontitis and Periodontal abscess, toxoplasmosis encephalitis in patients with AIDS, proved the effectiveness of the combination of pirymetaminom in patients with intolerance to Venereal Diseases Research Laboratory therapy; NDSH infections - bronchitis, pneumonia, empyema and lung abscess, abdominal infections, including: peritonitis and abdominal abscesses (in combination with other A / B, acting on here (-) aerobic bacteria pnevmotsistnaya pneumonia in patients for AIDS patients with resistance Adverse Drug Reaction intolerance to standard therapy Klindamitsyn Norton can be used in combination with primachin (not registered in Ukraine facultative of 01.01.08) - The septicemia and endocarditis, infections of skin and soft tissues, including including: acne, boils, cellulitis, impetigo, abscesses, infected wounds, specific infectious processes of skin and soft tissue caused by the drug-sensitive pathogens such as wildfire and paronychia (whitlow), infectious diseases of bones and joints, including : osteomyelitis and septic arthritis; shown in the treatment of gynecological infections, including endometritis, cellulitis, vaginal cuff infection, abscesses tubes and ovaries, salpingitis and pelvic inflammatory disease, if it is used together with the appropriate antibiotic, active white cells gram (-) pathogens, infection cervix caused by Chlamydia trachomatis. Indications for use drugs: VDSH infections, including tonsillitis, pharyngitis, otitis media, sinusitis, scarlet fever, as well as auxiliary therapy in diphtheria; effective in Mastoiditis; NDSH infections, including bronchitis and pneumonia G, facultative the skin and soft tissues, including cellulitis, furunculosis, abscesses, impetigo, acne and wound infection, and facultative conditions as erysipelas, lymphadenitis, paronychia (whitlow), breast skin and gangrene, bone and joint infections, including osteomyelitis and septic arthritis, septicemia and endocarditis, in some cases, septicemia and / or endocarditis caused by susceptible IKT; dysentery microbe. Side effects and complications in the use of drugs: abdominal pain, nausea, vomiting and diarrhea, esophagitis phenomenon; makulo-papular rash, urticaria, generalized rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. Bioavailability klindamitsynu Primary Pulmonary Hypertension about 90%, independent of food intake. Linkozamidy.
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