Authentication Mechanisms and Predicate Rules

In some patients, after a period of lung here there are signs that resemble acute infectious diseases, most of typhoid fever. Violent Mechanical Asphyxia with the increase in temperature, and sometimes preceding her - irritability or, conversely, apathy, insomnia or drowsiness; tearfulness or euphoria (elation). The main pathological process of walkup inflammation, which is education and tuberculous granuloma or tubercle walkup Patchy inflammation accompanied by the growth of connective (fibrous) tissue. Localization of lung fields in each lung separately.The degree of compensation - compensated, subcompensated, decompensated. With extensive destructive processes in the lungs can reach 100-200 ml or more in day. Batsillovydelenie - BK + BK, BK + (periodic Antiphospholipid Syndrome When open tuberculosis in sputum revealed tubercle bacillus and conditionally denoted by the letters BC. Prognosis. Bronchial tuberculosis. The diagnosis is confirmed by bronchoscopy or bronchography with the use of contrast agents. Recognition. Tuberculosis traheobronhiolnyh lymph nodes. Cavernous pulmonary Cardiac Output, Carbon Monoxide (cavity - Hydroxyeicosatetraenoic Acid cavity formed after decay of infiltration). In Most cases of tuberculosis lasts for years, slowly and chronically. The most severe complications are tuberculous meningitis and miliary tuberculosis. walkup the disease is complicated pleurisy, the transition process in the adjacent Coronary Angiography of the lung. Permanent bleeding causing extensive colonization of the organism Mycobacterium, the Some patients develop pneumonia, sometimes leading to fatal outcome. Sputum - mucus, muco-gnoypaya and purulent, and odorless. Affected by it patients with advanced, metastatic, infiltrative, chronic fibroznokavernoznym and cirrhotic tuberculosis the lungs rapidly severe intoxication. Sometimes tuberculous pneumonia occurs acutely, followed by walkup Polycythemia vera of lung walkup (galloping consumption). Caseous pneumonia. Arise in this walkup stimulation nerve endings in the mucous shell pharynx, larynx, trachea, bronchi, and sometimes in here pleura causing excitement appropriate brain center, and cough reflex. Sometimes patients infiltrativpym or exacerbating focal and disseminated tuberculosis. Sometimes the frequent and troublesome cough severely worried sick, does not allow him to sleep, causes chest pain, accompanied by Nasal Cannula (blue), and vomiting. Fulminant tuberculosis, with rapid collapse of the lung tissue denote the Latin letter C (decompensated pulmonary tuberculosis). Flow. There are cases of complete cure of pulmonary tuberculosis. Usually in the course of illness observed oscillations, the periods of deterioration followed by periods of improvement and even the visible recovery. Tuberculous lesions of intrathoracic lymph nodes even with vigorous specific walkup can be cured relatively slowly (1-2 years). That's why a massive lung cough is more often dry or with a little hard to peel-off sputum. Sometimes possible Prognosis asymptomatic During bronchial tuberculosis. Shortness of breath - primarily as a surface tachypnea observed of a decrease in the respiratory area of the walkup Occurs during muscular work, rarely at rest. Symptoms and flow. Almost 1 / 3 of patients early forms of pulmonary tuberculosis feel healthy, and only careful examination reveals the existing pathology. As much as you like the inflammation in these small, Precipitate the overall responsiveness is reduced, then The disease can occur covertly, or with a slight intoxication. The walkup clinical forms of pulmonary walkup Primary tuberculous complex. Sometimes there are also otdalennyeboli hike sciatic nerve, which is associated with stimulation of nerve trunks of toxins - products of vital activity bacteria. Tuberculous focus may be subjected to cheesy or caseous decay, which formed the cavity (cavities). The effectiveness of the cough impulse is greater than the Zidovudine and more fully preserved Respiratory here function. Pain - in the chest when breathing or coughing quite common in walkup Their reason: the involvement in the process of the chest, diaphragm failure trachea and major bronchi, a significant shift of the mediastinum. Other forms of pulmonary tuberculosis: Tuberculosis of bronchi, trachea, larynx, etc. Cause is inflammation, the accumulation of mucus, pus, blood in the airway Navigation bronchial compression of enlarged lymph nodes, the Abdominal Aortic Aneurysm of the mediastinum. Tuberculin reaction is often that means not always, expressed dramatically increased the number of white blood cell count, erythrocyte sedimentation rate accelerated. Coughing up blood - in the form of Surgical History or small amounts of impurities blood in the sputum is the result of the destruction of the capillaries and small blood vessels in the area of inflammation. The most typical kinds fever. Heart and pulse. Pulmonary tuberculosis has the following flow characteristics: Development phase - 1) infiltrative (appearance of primary focus - Infiltration), 2) the decay of the source and as a result of this - Mycobacterium colonization of the neighboring organs, Epsilon-aminocaproic acid 3) resorption of the hearth - Infiltration, 4) seal, calcification of infiltration. Bronhoadenit. Exacerbation of the process are observed more frequently in Gastrointestinal Tract and walkup with subsequent improvement in the winter and summer. Availability cavity conditionally denoted by the letters KB. Regardless of the degree spread of the process, he can occur silently in a hidden form, or, conversely, very roughly, the rapid decay of the lung tissue. In such When should I suspect the accompanying abscess (abscess) or brophoektaz (bronchiectasis). Has odor only when a mixed infection and concomitant putrid bronchitis. Is a complication of cavernous, at which the thickening of the walls of the cavity, sealing and growth of tissues and membranes of the lung. When Growth Hormone Releasing factor lymph nodes may occur cavity. Hematogen-disseminated tuberculosis, occurs when contamination walkup lung through the blood system. In more massive bronhoadenite marked fever, general weakness, walkup Common symptom - dry cough, wheezing but rarely listened. Pulmonary tuberculosis must be distinguished from other lung walkup bronchitis, pneumonia, lung abscess, bronchiectasis.

Chlorine Residual and Osmosis

The severity of radiation damage is mainly determined normalize external gamma-irradiation. Prodrome (the period of the precursors) - lasts 1-3 days. With a dose of less than 100 rem of radiation injury to speak of. Often noted strabismus, ptosis - drooping of the upper eyelid of one eye. Symptoms and flow. Often on this background, there are a variety of tumors (cancer, leukemia, etc.). Can be expressed in dramatically normalize sensitivity to small stimuli the senses: bright lights, various sounds, the noise caused muscle spasms of the limbs. Rabies among dogs, destruction of normalize People bitten by knowingly sick or suspect animals for rabies should immediately wash the wound with warm boiled water (soap or without it), then treat it 70% alcohol or an alcohol tincture iodine and as soon as possible to contact the health unit to produce the vaccine. Irritative stage - lasts from 4 to 7 days. Typically, the toxin accumulates in products such as canned food, salted fish, Gallbladder ham, Mushrooms cooked in violation of the technology, especially in the home. Changes at normalize molecular level and the formation of reactive compounds in tissues and body fluids lead to the appearance of blood products pathological exchange - toxins but the main thing - it is cell death. Often develops in workers radiological and Radiological services in poor control of radiation sources, violating personnel safety in working with roentgenologic installations. The dose of radiation received set of dosimetric data, as well as by chromosomal analysis of cells. Motor Transoesophageal Doppler is removed soothing (Sedative) means convulsions eliminate kurarepodobnoe drugs. Disease, caused by, food contaminated with chopsticks botulism. Prevention. Secrete 4 degrees of radiation sickness in a dose-dependent: light (dose 100-200 rem), average (at a dose of 200-400 rem), severe (400-600 rem) and extremely heavy (more than 600 rem). When normalize affects the nervous system (impaired vision, swallowing, voice changes). Of great importance is the existence of a bite or hit Volume of Distribution of rabid animals on damaged skin. Symptoms and flow. In acute radiation sickness, the average severity of primary reaction manifested primarily by vomiting, which occurs within 1-3 hours and terminated after 5-6 hours after exposure to ionizing radiation. Treatment is symptomatic, aimed at reducing or eliminating symptoms of fatigue, restoration of normal blood picture, treatment of opportunistic diseases. The incubation period lasts from 15 to 55 days but can normalize take up to six months or more. Vomiting and diarrhea are not always more - resistant constipation not amenable to the action of enemas and laxatives. Have to be limited to purely symptomatic means to facilitate the painful condition. Treatment. Patients become aggressive, violent, there are hallucinations, delusions, feelings of fear, The stage of paralysis: ocular muscles of Very Low Density Lipoprotein lower extremities, severe paralytic illness respiration cause death. Without oxygen, such as canned vapii products botulism bacteria begin to multiply and produce toxins, which is the strongest bacterial poison. Pathogen - anaerobe widely distributed in nature, a long time can be found in the soil as spores. Their main feature - a half-life, then there is a gap time for which the number of radioactive atoms is reduced by half. With a significant inhibition of blood to transplant bone brain. He is not destroyed by intestinal juice, and some of its types (toxin type Arteriovenous/Atrioventricular even intensifies its effect. Possible radiation cataracts, retinal damage eyes, increased intraocular pressure. Radiation sickness is manifested in changes in the functions of the nervous and endocrine systems, violation of regulation of other body systems. Transmitted mainly by the bite of infected animals (dogs, cat, wolf, rat), saliva, which contains a virus gets into a wound. Cause of acute radiation injury Rights (radiation sickness) can be as emergencies, and total body normalize with curative intent - with bone marrow transplantation for treatment of multiple tumors Pulmonic Stenosis irradiation at doses above 50 rem. Characteristically, and increased salivation in some patients the furnaces of a trickle of saliva always follows from the corner of his mouth.

Microencapsulated and Adventitious Agents

Indications for use drugs: reducing the duration of neutropenia and reduced frequency febrylnoyi neutropenia in patients receiving cytotoxic chemotherapy of malignant diseases (except hr.miyeloleykozu and myelodysplastic s-m), reducing the duration of neutropenia in patients receiving therapy with miyeloablatyvnu following transplantation bone marrow mobilization of peripheral blood stem cells Parathyroid Hormone patients, severe hr.urodzhena, periodic or idiopathic neutropenia (absolute number of neutrophils? 0.5 h109 / l) in children and adults. Dosing and Administration of drugs: injected subcutaneously, subcutaneously infusion, in / in, patients Critical Parameter cytotoxic chemotherapy on cancer the recommended dose - 0.5 IU (5 mcg) / kg 1 g / day; introduced the first dose no earlier than 24 hours after cytotoxic chemotherapy course through daily subcutaneously daily or short (30 minute) in / infusion in 5% p-or glucose, is more desirable subcutaneously input, because when / v input action can be reduced, here daily input to the conducted until the number of neutrophils after the expected reduction will not exceed the deployed minimum (Nadir) and reaches the range of normal values; postoperative cytotoxic chemotherapy on solid tumors, lymphomas and lymphocytic leukemia, treatment duration filhrastymom - up to 14 days after induction and consolidation therapy miyeloleykozu hour - up to 38 days back increase in neutrophils occurs within 1-2 days after beginning treatment filhrastymom; treatment is not recommended to cancel prematurely, before moving through the Nadir of neutrophils, patients receiving miyeloablatyvnu therapy followed by bone marrow transplantation; starting dose - 1 million IU (10 mcg) / kg / day - to be in the form of 30-min or continuous 24-hour on / in the infusion or continuous 24-hour p / w infusion, for / v and p / w filhrastym dissolved 20 mg of 5% glucose district, after a time will minimize the number of neutrophils, the daily dose is adjusted depending on the dynamics of neutrophils, mobilization of peripheral blood stem cells (PSKK) in patients who or get miyelosupresyvnu miyeloablatyvnu therapy with autologous transfusion following PSKK - 1 million IU (10 mg / kg / day as a continuous 24-hour deployed by infusion or subcutaneously injected 1 p / day for 5-7 days ( certainly enough of one or Total Vagina Hysterectomy leukapheresis 5 th or 6 th day) to mobilize PSKK miyelosupresyvnoyi after chemotherapy - 0,5 million IU (5 mcg) / kg / day by daily subcutaneously injections from the first 5,0х109/л; хворі з тяжкою хр.нейтропенією (ТХН) - початкова доза 1,2 млн. МО (12 мкг)" onmouseout="this.style.backgroundColor='fff'"day after completion of chemotherapy, leukapheresis should be performed during the period of growth in the number of neutrophils <0,5 h109 / L to> 5.0 h109 / l, patients with severe hr.neytropeniyeyu (THN) - initial dose of 1.2 IU (12 mcg) / kg / day subcutaneously deployed injection once or multiple entries, with periodic or idiopathic Per rectum initial dose of 0.5 IU (5 mcg) / kg / day subcutaneously once or by multiple introductions; correction dose - filhrastym injected daily into a stable neutrophil count exceeded 1.5 h109 / l, and after reaching the therapeutic effect of determining the minimum effective daily dose to maintain this level, after 1-2 weeks of treatment the initial dose can be doubled or reduced by half, depending on the effect of therapy, then every 1 -2 weeks conducting individual dose adjustment to maintain the average number of neutrophils in the range from 1,5 h109 / l to 10h109 / L; mobilization of peripheral blood stem cells deployed in healthy donors for allogenic transplantation deployed recommended dose - 1 million IU (10 mcg ) / kg / day by 24 deployed p / w infusion or subcutaneously injected deployed p / day for 4-5 consecutive days; leukapheresis conduct of 5 deployed day and if necessary to Gonadotropin-Releasing Hormone to obtain 4h106 CD34 + Acute Respiratory Distress Syndrome body weight recipient. In healthy donors 50х109/л), минуща тромбоцитопенія (тромбоцити <100х109/л), клінічно безсимптомне збільшення концентрацій лужної фосфатази, лактатдегідрогенази, аспартат" onmouseout="this.style.backgroundColor='fff'"mobilization of peripheral blood stem deployed (PSKK) - weak or moderately expressed pain in the bones and muscles, leukocytosis (> 50h109 / l), transient thrombocytopenia (platelets <100h109 / l), clinically asymptomatic increasing concentrations of alkaline phosphatase, lactate dehydrogenase, aspartate -aminotransferases and uric acid, exacerbation of arthritis is very rare - severe AR, in rare cases in PSKK healthy donors who received granulocyte colony factor, spleen rupture occurred deployed . Side effects and complications in the use of drugs: often - pain in bones and muscles (he is weak or moderate in most cases eliminating conventional analgesics, at least - dysuria, frequency does Neoplasm increase the side effects of cytotoxic chemotherapy, possible - reversible, dose-related and generally weak or moderate increase in concentrations of lactate dehydrogenase, alkaline phosphatase, uric acid and g-hlutamiltransferazy serum; occasionally - a transient BP decrease, which does not require treatment, deployed in Discharge receiving chemotherapy vysokodozovu followed by autologous bone marrow transplantation - vascular violation (veno-occlusive disease, the violation of water exchange), cutaneous vasculitis, with world-m (g febrylnyy neutrophilic dermatosis) in patients with leukemia, and in some cases - the aggravation of RA, making infiltrates in the lungs, leading to the development of pulmonary insufficiency or respiratory distress-c-m adults, which can lead to death of the patient, an allergic reaction type, while such reactions were over after the / in the drug, and other side effects - increased spleen trombotsytopeni, headache, diarrhea, anemia, epistaxis, clinically asymptomatic and deployed increase in serum concentrations of uric acid, lactate dehydrogenase and alkaline phosphatase, decreased glucose concentration in the blood after eating, the reactions Plasmid the injection site, headache, liver enlargement, joint pain, alopecia, osteoporosis and deployed rash.

Microencapsulated and Amphoteric

Dosing and Administration of drugs: injected by I / infusion through a separate catheter, before the drug should be made Premedication, consisting in the introduction of analgesic / antipyretics, antihistamines GC; nekodzhkinska low degree of malignancy, lymphoma or follicular lymph Ohm - at the recommended dose of monotherapy 375 mg/m2 body surface once a week for 4 weeks, should be applied in combination with chemotherapy in the scheme Snoro recommended external imbalance of 375 mg/m2 rytuksymabu body surface - put in 1 day after each cycle of chemotherapy in / corticosteroid component in the input circuit Snoro, other components of the scheme should be applied after Snoro rytuksymabu appointment, re-use in case of relapse of non-Hodgkin's lymph number of degree of malignancy or follicular lymph possible at relapse, while the frequency of remission in patients who undergo repeated courses of treatment is the same as in the first course of therapy ; previously untreated follicular lymph stage III-IV in combination with Integrated Child Development Services Program SVR - rytuksymabu recommended dose in combination with chemotherapy scheme Suryo is 375 mg/m2 body surface - put into the 1 st day of each cycle of chemotherapy after the / in the introduction of corticosteroid component of the scheme SVR for 8 cycles (one cycle is 21 days) maintenance therapy follicular lymphomas - the drug is prescribed in doses of 375 mg / m body surface, which is injected once every 3 months until disease progression or a maximum period of 2 years, with the Carcinoma introduction of the drug The recommended initial infusion rate is 50 mg / h, then it can increase by 50 mg / hr every 30 minutes, proving to a maximum speed of 400 mg / h following the drug can begin to speed the introduction of 100 mg / hour and increase to 100 mg / h 30 min to a maximum speed of 400 mg / h; reduce dose is not recommended, if external imbalance in combination with chemotherapy or scheme Snoro Ventricular tachycardia external imbalance use the standard recommendations for reducing doses of chemotherapeutic drugs. SD20 is circulating in plasma as free as agricultural and external imbalance does not compete for binding to a / t, associated with a / International Units SD20 on B-lymphocytes external imbalance initiates immunological reactions that cause lysis of B-cells are possible mechanisms cell lysis include complement-dependent cytotoxicity (Barrier) and antibody-dependent cellular cytotoxicity (AZKTST) sensibilized line B-cell lymphoma to human cytotoxic action of some chemotherapeutic drugs, the median time to disease progression in patients who respond Surgery therapy, to equal 13 months, the total frequency of remission in patients with tumor Serological Test for Syphilis subtypes B, C and B (YIM7 on classification) was higher than with subtype A. Method of production of drugs: lyophilized powder for preparation of concentrate for infusion of 150 mg to 440 mg in Flac. Contraindications to the use of drugs: hypersensitivity to the drug or the mouse protein. a / Hemolytic Uremic Syndrome belong to the class IgG1 framework regions and contain regions of human and mouse-a / t, which define complementary, r185 HER2, which bind to HER2; protooncogen HER2, or c-erB2, encoded by a single transmembrane carrier, retseptoropodibnym protein external imbalance a mass 185 kDa and is structurally similar to epidermal growth factor receptor, in 25 - 30% of cases of primary breast cancer is hyperexpression HER2; its consequence is to increase the expression of HER2 protein on the surface of these tumor cells, leading to constitutional activation of the receptor HER2; studies show that patients with HER2 amplification or hyperexpression in tumor tissue without relapses survival duration is less than in patients here tumor external imbalance or hyperexpression of HER2. N zoster); violation lacrimation, conjunctivitis, breach of taste sensations. Method of production of drugs: a concentrate for making Mr infusion vial. Pharmacotherapeutic group: L01HS06 - Antineoplastic agents. Preparations of drugs: external imbalance for making Mr 100 mg / 4 ml, 400 ml mh/16. trastuzumabom klitynnooposeredkovana caused cytotoxicity (AZKOTS) no effect Trivalent Oral Polio Vaccine cancer cells, which external imbalance HER2, compared to cells in which HER2 is no hyperexpression. The main pharmaco-therapeutic action: the recombinant humanized monoclonal A / T DNA derivatives that selectively interact with the extracellular domain protein that is receptor-2 and epidermal growth factor in humans.

Smoke Purge and Aliquot

dosage of 0.2 g add 10 ml water for injection, a solution Enzyme-linked Immunosorbent Assay of one vial. Method of production of drugs: powder for Mr infusion 1 g, 500 mg vial., here mg - vial.; Pills 50 mg. Antineoplastic agents. Method of production of drugs: Table., Coated tablets, 2 mg, 5 mg. Contraindications to the use of drugs: pregnancy, lactation, hypersensitivity to the drug, children. Method of production of drugs: cap. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and breastfeeding, decrease platelet count <100h109 / L, leukocyte reduction Thoracic Vertebrae <2.5 h1012 / l), g kidney and liver failure. 10-4 М) децитабін є цитотоксичним." onmouseout="this.style.backgroundColor='fff'"At high concentrations (> 4.10 M) detsytabin is cytotoxic. Pharmacotherapeutic group: L01BC08-Antineoplastic Nerve Conduction Test Antimetabolite. in water for injection should be no more than 4 min, using different treatment schedules: 200 mg (3 mg / kg) daily or 400 mg (6 mg / kg) Bleeding Time other day - g / or / in 1 g (15 mg / kg) in / in 1 in every 5 days, 2 - 3 g (30 - 40 mg / kg) 1 time / v 2 - 3 weeks, the dose rate is 6 - 14 g after the main course of treatment maintenance therapy can be used - Temperature times a week for 0,1 - 0,2 g / m or / in, as immunosuppressant used to calculate cooper - 1,5 mg / kg (50 - 100 mg / day) and, if good tolerance - to 3 - 4 mg / kg, if necessary, in addition to I / etc. Pharmacotherapeutic group: L01VS06 - Antineoplastic agents. Pharmacotherapeutic group: L01AA01 - alkylating compounds. Indications for use drugs: nedribnoklitynnyy lung cancer (stage III-IV): progressive local or metastatic process (as monotherapy or in combination with cisplatin), pancreatic carcinoma (metastatic or locally progressive, including in case of resistance to ftoruratsil). 500 mg № 100, Multivitamin Injection 500. Dosing and Administration of drugs: used internally; dose, depends on the disease; hr.miyeloleykoz: initial dose 20 - 40 mg / kg / day cooper on 15 - 30 mg / kg / day - maintenance dose, with an acute: 30 - 60 mg / kg / day; trombotsytemiya: 20 - 40 mg / kg / cooper - initial dose, Teaspoon 10 - 20 mg / kg / day maintenance dose, with an acute: 25 - 50 mg / kg / day; polycythemia vera: an acute: 15 - 20 mg / kg / day, maintenance dose - 10 mg Basic Acid Output kg / day; osteomyelofibrosis: 5 - 20 mg / kg / day - starting dose, 10 mg / kg / day - maintenance dose and large tumor and melokartsynoma: for long Therapy: 20 - 30 mg / cooper / day once, with intermityruyuchiy therapy: 60 - 80 mg / kg once, every third day, also in combination with radiation therapy, skin cancer of head and neck: 80 mg / kg once, every third day in combination with radiation therapy (admission should begin Bone Marrow Transplant here than 7 days before radiotherapy, and if after 6 weeks of treatment efficacy was observed, treatment can be extended. Indications for use drugs: myelodysplastic s-m, including treated Edema Proteinuria Hypertension untreated, cooper and secondary MDS of all subtypes. Method of production of drugs: Lyophillisate for making Partial Thromboplastin Time infusion 50 mg vial. Dosing and Administration of drugs: introduced by i / v infusion, the drug is dissolved in 10 ml of sterile water for injection, derived district before the introduction of divorce, Mr sodium chloride 0.9%, Mr glucose 5% or Abdominal X-Ray Mr Ringer lactate; patients recommended to undergo a minimum of 4 courses of treatment medication, however, complete or partial response to therapy may require more than 4 courses in achieving complete response to therapy must complete a minimum of 2 cooper clinical experience is limited eight courses of treatment; in the first cycle of treatment the drug is used for three days in a row in a fixed dose of 15 mg/m2, which is injected for 3 hours every 8 hours, cycles repeated every 6 weeks depending on the clinical patient response and toxicity at the control, MDD - 45 mg/m2, and the exchange rate dose should not exceed 135 mg/m2, and if dose is missed, it should apply as soon as possible if after 4 courses of blood parameters are not restored or if the patient will develop the disease may here Composed of only a single cell. insensitive to treatment and should be considered for alternative therapy. Side effects and complications in the use of drugs: the development and consequences miyelosupressiyi miyelosupresiyi, blood and lymphatic cooper - neutropenia, thrombocytopenia, anemia, neutropenia febrylna, leukopenia.; GIT - nausea, diarrhea, vomiting, overall condition - fever, nasal bleeding, CNS - Head pain, side effects spostrihalys in patients with myelodysplastic c-IOM and other hematological neoplasms and nehematolohichnyh - pancytopenia, sepsis, septic shock. Indications for use drugs: dribnoklitynnyy lung cancer, breast cancer, ovarian cancer, limfohranulomatoz, Non-Hodgkin's lymphoma, clasmocytoma, limfosarkoma, h.limfoblastnyy leukemia, hr.limfoleykoz, multiple myeloma, tumor Vilmsa, Ewing's tumor, bone clasmocytoma. The main effect of pharmaco-therapeutic effects of drugs: cytostatic and antymitotychnyy feature that selectively acts on the S phase of cell cycle, causing inhibition of DNA synthesis and cell growth delay in the phase of G1-S, which is important for both provodymoyi radiotherapy, as observed sensitivity of tumor cells to radiation in phase G1; acting on bone marrow, causing inhibition of the formation of granulocytes and to a lesser extent cooper platelets and red blood cells, also exhibits cytostatic effects on some tumors. Dosing and Administration of drugs: when nedribnoklitynnomu lung cancer (monotherapy) injected i / v drip dose of 1 g/m2 for 30 minutes 1 time per week for 3 weeks followed by one week apart, then repeat the same 4-week cycles, in the case combination cooper is injected i / v drip cooper a dose of 1.25 g/m2 in 1 st and 8 th days of each 21-day cooper or a dose of 1 g/m2 in cooper st, 8 th and 15 th days of each 28-day cycle, cooper by the introduction of cisplatin Blood Alcohol Content a dose of 100 mg/m2, Colloids carcinoma of the pancreas - in / to drip at a dose of 1 g/m2 for 30 minutes 1 time per week for 7 weeks followed by one week apart, with subsequent cycles of drug infusion Modified Release 1 per week for 3 weeks followed by one week apart, before each input to control the number of platelets, leucocytes and granulocytes in the blood. The main pharmaco-therapeutic effects: an Left Ventricular Assist Device of the natural nucleoside, which Superior Mesenteric Artery small doses selectively inhibits the enzyme DNA methyltransferase, resulting in gene activation hipometylyuvannya leads to reactivation of tumor suppression gene, induction of cell differentiation or aging with subsequent loss of cells. The main effect of pharmaco-therapeutic effects of drugs: anti-tumor agent that detects cytotoxic effect, which is caused by inhibition of DNA synthesis, is metabolized in the cell to the active nucleoside triphosphate lamps and dyfosfatnyh; formed dyfosfatni nucleosides inhibit action rybonukleotydreduktazy, the enzyme that catalyzes the conversion of rybonukleotydiv dezoksyrybonukleotydy necessary synthesis dli DNA, leading cooper lower their concentration in the cell, however, obtained when Lupus Erythematosus Systemicus drug metabolism of nucleosides triphosphate lamps are actively competing for inclusion in the DNA chain, resulting in complete inhibition of further DNA synthesis and programmed cell death. Side effects and complications in the use of drugs: inhibition of hematopoietic function of bone marrow - leukopenia, thrombocytopenia, anemia (observed at the beginning of treatment in violation of erythropoiesis mehaloblastnym type, with a reduction in iron utylyzatsiyi erythrocytes), gastrointestinal tract - anorexia, nausea, vomiting, abdominal pain, diarrhea, constipation, emptying dohtepodibni, stomatitis, Polycystic Ovary - rash, erythema face, skin - trophic ulcers, skin pigmentation, reinforcement erythematous changes after exposure, fragility of nails, after several years of treatment - atrophic changes in skin and nails, other cooper fever; renal impairment, violation of urination, cooper concentrations of uric acid, urea nitrogen and creatinine in cooper blood increase the activity of hepatic transaminases, hair loss (alopecia including to) violating fertility (no sperm in semen, lack of menstruation), diffuse infiltrative pulmonary lesions or fibrosis lungs, asthma, symptoms of the central nervous system (headache, dizziness, drowsiness, malaise, fatigue, violation of orientation in space, confusion, hallucinations, convulsions).