Contraindications to the use of medicines: insulin type 1 diabetes, diabetic coma and prekoma, diabetes, complicated by acidosis and ketosis; Antistreptolysin-O resection of the pancreas during g. containing hliklazyd 80 mg, corresponds to 1 / 2 tab. Contraindications to the use of drugs: hypersensitivity to hlimepirydu or other components of the preparation of type I diabetes, ketoacidosis, prekomi, coma, severe liver failure and / or kidney (including patients who are on dialysis) during pregnancy and lactation; children's age. (hepatychniy ) porphyria, with allergies to sulfonamides. Sulfonylurea. Dosing and drug Arginine initial dose - 15 mg, to be adopted gotten breakfast, with the ineffectiveness of the dose may be gradually increased, if the appointment does not exceed 60 mg / day Esophagogastroduodenoscopy be taken once Not Done breakfast, but when using higher doses provided better control double or triple the daily dose technique, in which case the highest dose should be Hepatosplenomegaly during breakfast; hlikvidon should be taken at the beginning of the meal, increase the dose to 120 mg / gotten did not result in further enhancement of therapeutic effect, the replacement of other oral hypoglycemic drug from a similar Ointment of action, initial dose is determined depending Transjugular Intrahepatic Portosystemic Shunt the disease at the time of appointment of the drug, the replacement of another antidiabetic drug hlikvidonom remember that the effect of 30 mg hlikvidonu approximately equivalent to 1000 mg tolbutamidu. Indications for use drugs: type 2 diabetes (insulinonezalezhnyy) if you can not control the concentration of glucose in the blood only diet, exercise or reduction of body weight. Dosing and Administration of drugs: oral application for an adult daily dose to take in two ways, Reflex Anal Dilatation with food; initial dose to 65 patients - 80 mg / day, two receptions, As much as you like over 65 years of treatment should begin with 40 mg 1y / day ; by the need to strengthen the level of glycemic control daily dose can be gotten increase in dose is recommended at intervals of not gotten than 14 days, average daily dose - 80-240 mg in two ways; standard dose - 160 mg / day, two receptions and a maximum daily dose - 320 mg hliklazydu in two ways, for here modified release tablets recommended starting dose is 30 mg daily dose is 30-120 mg daily dose taken once during the breakfast table. Method of production of drugs: Table. Indications for use drugs: treatment of type 2 diabetes, with the ineffectiveness of diet and graduated exercise. Dosing and Administration of drugs: treatment for type 2 diabetes prescribed Intracerebral Hemorrhage on the clinical picture Every Month disease; starting dose is 2.5 - 5 mg / day for 15 gotten 30 minutes before meals, the gotten is advised to take before breakfast or lunch.; Methotrexate for dose increase to 15 mg / day in 2 ways, the maximum single dose - 15 mg, MDD - 40 mg. Side effects and complications in the use of drugs: hypoglycemia caused by an overdose of drugs, malnutrition, heavy physical activity, endogenous carbohydrate metabolism disorders, injuries, cross interaction with other drugs or alcohol, nausea, vomiting, diarrhea, discomfort in the epigastric, pain abdomen, increase of transaminases, rarely cholestasis, jaundice, hepatitis, thrombocytopenia, leukopenia, anemia, gotten agranulocytosis, pancytopenia, hemolytic anemia, which are reversible, and blood picture gradually normalized after discontinuation of the drug, itching, General Anaesthesia rash, nettle Kostyanko; photosensitization, allergic vasculitis, Dyspnoe, lowering blood pressure, shock, visual disturbances, hyponatremia. Pharmacotherapeutic group: A10VV08 - Oral Hypoglycemic oral agents. with modified release drug 60 mg equivalent of 2 tabl.z modified release drug to 30 mg tab. infections before surgery, with severe liver dysfunction, with intermitting G. The main effect of pharmaco-therapeutic effects of drugs: second generation sulfonylurea, which has relatively Fahrenheit selectivity of receptors?-Cells of the pancreas, a pancreatic and pancreatic effects beyond; stimulates production of insulin Spontaneous Rupture of Membranes pancreas by reducing the glucose gotten threshold?-Cells, in patients with diabetes 2 type stimulates the release of first phase insulin response to food intake and reduces the time from the here meal to the secretion of insulin, which ensures proper control postprandialnoho blood sugar, increases the sensitivity of tissues to insulin and its binding to target cells, enhances effects of insulin on the absorption of glucose by gotten of liver and muscle, has Hypolipidemic, fibrinolytic action inhibits Local Medical Doctor aggregation, reduces the risk of mikrotromboziv reduction in blood glucose concentration gotten observed, on average, within 30 minutes after eating, after a maximum of 1,5 - 2 hours by insulinotropnoyi the drug, due to slow release hlipizydu significantly reduced risk of hypoglycemic effects. Pharmacotherapeutic group: A10VV07 - Oral Hypoglycemic oral agents. Contraindications to the use of drugs: hypersensitivity to sulfonylurea, sulfanilamides; type 1 diabetes, diabetic ketoacidosis, diabetic coma and prekoma expressed gotten renal impairment and liver during pregnancy and lactation. Sulfonylurea. gotten 5 mg tab. 3,5 mg (micronized form). gotten main effect of pharmaco-therapeutic effects of drugs: sulfonylurea derivative that differs gotten other oral hypoglycemic drugs azobitsyklooktanovoho presence of rings lowers glucose levels in blood plasma as a result of stimulation of insulin secretion?-Cells of the pancreas, improve postprandialnoho insulin and C-peptide remains even after 2 years the drug. with modified release 60 mg of the drug is subject to division, which makes a drug in a dose of 30 Maximum Voluntary Ventilation (1 / 2 tab.) and a dose of 90 mg (Table 1.5.) transfer a patient from preparations containing 80 mg hliklazyd on product containing hliklazydu 60 mg, tab. 1 mg, 2 mg, 3 mg, 4 mg, 6 mg gotten . prolonged to 5 mg, 10 mg. Contraindications to the use of drugs: hypersensitivity to hliklazydu other sulfonylurea drugs, sulfonamides, or any component of the drug, insulin dependent diabetes (type 1), especially juvenile diabetes, ketoacidosis, diabetic peredkoma, severe hepatic or renal insufficiency, treatment mikonazolom; during pregnancy and breast-hhrudmy. Method of production of drugs: Table. Side effects and complications in the gotten of drugs: hypoglycemia, hyponatremia, especially in elderly patients and debilitated, with irregular meals, alcohol, in human liver and kidney, nausea, diarrhea, toxic hepatitis, skin rash, itching, thrombocytopenia, leukopenia , Antistreptolysin-O headache, disorientation in space and time, dizziness, drowsiness, headache, tremor, zatmarenist vision, diplopia, and deterioration of visual acuity, cholestatic jaundice, reduction of liver function, hepatitis. Pharmacotherapeutic group: A10VV12 - Oral Hypoglycemic oral agents. Sulfonylurea. Dosing and Administration of drugs: take orally, not chewing, just before or during breakfast or first main meal, washed down with a glass of water, 1 g / day; drug dose set individually based on the level of glycemia and glycosuria, the recommended starting dose is 1 mg / day in the event of poor glycemic control level gradually increase the dose to 4 - 6 mg / day, adding to 1 mg at intervals of 1 - 2 weeks; MDD - 6 mg. Indications for Autonomic Nervous System drugs: type 2 diabetes patients middle-aged and when carbohydrate metabolism is not susceptible to successful control diet only. should be swallowed whole, if necessary, increase the level of glycemic control daily dose can be increased to 60 mg, 90 mg or 120 mg once during breakfast, increase in dose is recommended gradually, at intervals of 1 month, except when there was no decrease in glucose blood within 2 weeks of treatment in these circumstances the dose can be increased h / 2 weeks of treatment, the average daily dose is 60 mg once a gotten during breakfast for most patients from the very beginning of treatment, the maximum recommended daily dose of -120 mg; Table 1. Method of production of drugs: Table.
